This study examines how random variations in climate may influence future ice loss from the Greenland ice sheet. We find that random climate variations are important for predicting future ice loss from the entire Greenland ice sheet over the next 20–30 years but relatively unimportant after that period. Thus, uncertainty in sea level projections from the effect of climate variability on Greenland may play a role in coastal decision-making about sea level rise over the next few decades.