The Northern Patagonian Icefield is the second largest ice mass of South America, located at moderate latitudes. Using an ice-flow model which uses available atmosphere data as input and explicitly models iceberg discharge, we assess its evolution. With present climate, it will lose about 36 % until the year 2200. Climate change strongly accelerates losses and under Paris Agreement compliance it is between 38% and 75%  and between 81% and  94% under a business-as-usual fossil fuel scenario.