Inspired by a previous intercomparison framework, our study better constrains uncertainties in glacier evolution using an innovative method to validate Bayesian calibration. Upernavik Isstrøm, one of Greenland's largest glaciers, has lost significant mass since 1985. By integrating observational data, climate models, human emissions, and internal model parameters, we project its evolution until 2100. We show that future human emissions are the main source of uncertainty in 2100, making up half.