We simulate the current state and future evolution of the Mocho-Choshuenco ice cap in southern Chile (40°S, 72°W) with the ice-sheet model SICOPOLIS. Under different global warming scenarios, we project ice mass losses between 56 % and 97 % by the end of the 21st century. We quantify the uncertainties based on an ensemble of climate models and on the temperature dependence of the equilibrium line altitude. Our results suggest a considerable deglaciation in southern Chile in the next 80 years.