The glacier runoff changes are still unknown in most of the Andean catchments, thereby increasing uncertainties in estimating water availability, especially during the dry season. Here, we simulate glacier evolution and related glacier runoff changes across the Andes between 2000 and 2019. Our results indicate a glacier reduction in 93 % of the catchments, leading to a 12 % increase in glacier melt. These results can be downloaded and integrated with discharge measurements in each catchment.