We used satellite images to create a comprehensive record of annual glacier change in northwest Greenland from 1972 through 2021. We found that nearly all glaciers in our study area have retreated and glacier retreat accelerated from around 1996. Comparing these results with climate data, we found that glacier retreat is most sensitive to water runoff and moderately sensitive to ocean temperatures. These can affect glacier fronts in several ways, so no process clearly dominates glacier retreat.