Dear Gabriele Arduini and coauthors,

Thank you for submitting your detailed responses to the reviewers’ comments. Based on the open discussion, I have judged that major revisions are necessary before considering its publication in TC. However, I have found that the revisions you plan are promising. Therefore, I invite you to submit a revised version of your manuscript. In the submission, I need your complete responses to the review comments, along with a copy of the revised manuscript that tracks and highlights the changes made.

I look forward to receiving your revised manuscript.

Sincerely,
Masashi Niwano

Dear Gabriele Arduini and coauthors,

Thank you for submitting the revised manuscript and detailed responses to the earlier review comments. Anonymous Referee #1 reviewed the revised manuscript, and the referee is generally satisfied with your responses, although the referee has provided some additional useful comments/suggestions, which I would like to ask you to consider. I also checked your responses to Referee #2’s review comments and found that they are convincing. Based on the review results, I have decided to publish this paper after minor revisions. Please revise the manuscript considering the comments/suggestions provided by Anonymous Referee #1.

I look forward to receiving your revised manuscript.

Sincerely,
Masashi Niwano

Dear Gabriele Arduini and coauthors,

Thank you for considering the review comments carefully and submitting the revised manuscript. I have checked your responses to the review comments and judged that the revision is appropriate. Therefore, I am pleased to accept the paper as is. In the next step, please follow the copy-editing suggestions.

Sincerely,
Masashi Niwano