Estimating meltwater runoff from mountain glaciers is challenging due to harsh conditions and uncertainties in glacier runoff models. Using high-resolution unmanned aerial vehicle data, we extracted the complete supraglacial stream network on Qiyi Glacier (Tibetan Plateau) and its geometric parameters to build regression models estimating annual meltwater discharge with high accuracy. These methods show potential for large-scale glacier runoff estimation with improving remote sensing resolution.