Cosmogenic-nuclide analyses in bedrock recovered from below the West Antarctic Ice Sheet have the potential to establish whether and when large-scale deglaciation occurred in the past. Here we (i) discuss the criteria and considerations for subglacial drill sites, (ii) evaluate candidate sites in West Antarctica, and (iii) describe reconnaissance at three West Antarctic sites, focusing on the Pirrit Hills, which we present as a case study of site selection on the scale of an individual nunatak.