Snow and ice provide large amounts of meltwater to the Indus, Ganges and Brahmaputra rivers. In this study we show that climate change will reduce the amount of snow falling in the Himalayas, Hindu Kush and Karakoram substantially. The limited number of observations in remote upper-level terrain makes it difficult to get a complete overview of the situation today, but our results indicate that by 2071–2100 snowfall may be reduced by 30–70% with the strongest anthropogenic forcing scenario.