<p>Thanks to its insolubility, mineral dust is considered a stable proxy in polar ice cores. With this study we show that below an ice-depth of 1000 m, the Talos Dome ice core (Ross Sea sector of East Antarctica) presents evident and progressive signs of post-depositional processes affecting the mineral dust records. We applied a suite of established and cutting edge techniques to investigate the properties of dust present in the Talos Dome ice core, ranging from concentration and grain-size to elemental-composition and Fe-mineralogy. Results show that through acidic/oxidative weathering, the conditions of deep ice at Talos Dome promote the dissolution of specific minerals and the englacial formation of others, deeply affecting dust primitive features. The expulsion of acidic atmospheric species from ice-grains and their concentration in localized environments is likely the main process responsible for englacial reactions and is related with ice re-crystallization. Deep ice can be seen as a "geochemical reactor" capable of fostering complex reactions which involve both soluble and insoluble impurities. Fe-bearing minerals can efficiently be used to explore such transformations.</p>